Tara Urban-Engel's question in Czech Republic

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What is the best way to travel around the Czech Republic? Is bus or train available to most ‘highlights’ (ex. Cesky Krumlov, Sedlec Ossuary, Telc, Olomouc) and is it easy enough to get a ticket speaking English?

4 PEOPLE HAVE ANSWERED THIS QUESTION
You need a train to get outside of Prague. The train station is very Czech dominated but since you’re in Prague still you can find an English speaker to help you obtain a ticket. Just keep in mind once you leave Prague the amount of people who speak English are very limited.
I agree that outside of Prague English-speakers become much more hard to come by. You can definitely get to the main places by bus or train (I’d recommend Student Agency for buses), but if it’s at all possible, I’d suggest renting a car. You can see some really wonderful small towns and countryside… 
Just to let expand on the Student Agency option Sita suggested - it is an excellent service and one which I recommend when commuting to Prague. The service offers free teas and coffees on board, neat little TV screens in front of your seat, like in a airplane to watch movies and flexibility of… 
* as Lenny suggested